Disrupting the PCSK9/LDLR protein-protein interaction by an imidazole-based minimalist peptidomimetic.
نویسندگان
چکیده
Herein we report on the multicomponent synthesis of a novel imidazole-based compound, able to act efficiently as a minimalist β-strand mimic. Biological evaluation proved its ability to impair the LDLR-PCSK9 protein-protein interaction, disclosing it as the first small molecule exerting a PCSK9-mediated hypocholesterolemic effect.
منابع مشابه
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 14 41 شماره
صفحات -
تاریخ انتشار 2016